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![]() Using CRISPR allows the scientists to induce a break and follow how the cells choose to repair the damage. Previous attempts to do so involved unwieldy technology using radiation, which damaged DNA indiscriminately, making it incredibly hard to follow the repair pathway. "These developments fill this team with hope in humanity's renewed quest to explore and inhabit the vast expanse of space."ĬRISPR has become the figurehead for medical advancements in recent years, owing to its impressive ability to target specific regions of DNA and modify them, whether that be to insert a sequence or delete one. This ability makes it the perfect tool to induce double-stranded breaks under controlled conditions in space. ![]() "It's not just that the team successfully deployed novel technologies like CRISPR genome editing, PCR, and nanopore sequencing in an extreme environment, but also that we were able to integrate them into a functionally complete biotechnology workflow applicable to the study of DNA repair and other fundamental cellular processes in microgravity," said senior author Sebastian Kraves in a statement. Now, in an effort to study how astronauts’ DNA gets damaged and repaired, scientists have demonstrated the first case of CRISPR technology being used entirely in space. The incredible feat was conducted on yeast cells and allows scientists an unprecedented look into the DNA repair pathways chosen under space conditions, which was previously impossible due to safety obstacles. The results have been published in the journal PLOS ONE. ![]()
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